Description:Paclitaxel-treated cells have defects in mitotic spindle assembly, chromosome segregation, and cell division. Unlike other tubulin targeted drugs such as colchicine that inhibit microtubule assembly, however, paclitaxel stabilizes the microtubule polymer and protects it from disassembly. The inability of the chromosomes to achieve a metaphase spindle configuration leads to a mitotic block in which there is prolonged activation of the mitotic checkpoint with the subsequent triggering of apoptosis or slippage back into the G1-phase of the cell cycle without cell division.The ability of paclitaxel to inhibit spindle function is generally attributed to its suppression of microtubule dynamics;but recent studies have demonstrated that suppression of dynamics occurs at concentrations lower than those needed to block mitosis. At the higher antimitotic concentrations, paclitaxel appears to act by suppressing microtubule detachment from centrosomes, a process normally activated during mitosis.The binding site for paclitaxel has been shown to reside on the beta-tubulin subunit.

01    Red Clover extract          Isoflavones8-40%
02    Resveratrol                 20-98%
03    Galanthamine HBr           99%
04    Limonin                   98%
05    Gingko Biloba Extract        CPh,USP,DAB,EP
06    Ginseng extract              Ginsenosides 80%
07    Milk Thistle extract         Silymarins80%
08    Epimdium extract           Icariin 10%-98%
09    Lycopene                 5%-90%
10    Griffonia Seed extract        5-HTP 98%
11    Horse Chestnut extract      Aescin 20-98%
12    Zeaxanthin                  5%-50%
13    Grape Seed extract         Polyphenols85%,95%;OPC 95%,98%
14    Bilberry Extract              Anthocyanidins 25%
15    Saw Palmetto extract         Total fatty acids 25%,45%
16    Huperzine A                1%,5%,98%
17    Lutein                     5-90%
18    Soybean extract             Soy Isoflavones 20-40%
19    SOD                       3000IU/mg
20    Schisandra extract          Schisandrins 1-9%
21    Yohimbine Hydrochlori     98%
22    Stevia Extract             Steviosides 80%-97%
23    Black Pepper extract          98%piperine
24    Tribulus Terrestris extract   Tribuloside 40%-90%
25    St Johns Wort extract       Hypericin 0.3%
26    Rhodiola extract             Salidroside 1-10%,Rosavins3%
27    Ginger Extract                   Gingerols 5%
28    Reishi Mushroom Extract   Polysaccharides 10-60%;triterpene 1-6%
29    Green Tea Extract          Polyphenol 40-98%
30    Citrus Auratium Extract     Synephrine 6-98%
31    Echinacea Extract           Total phenol 4%;Cichoric acid 4%
32    Rosemary Extract           Carnosic acid 5-90%;Rosmarinic acid 2.5-20%
33    White Willow Bark Extract  Salicin 15%~50%
34    Wild Yaw Extract          Diosgenine8-20%
35    Angelica Extract             Ligustilide 1%
36    Kudzu Root Extract               Isoflavones/ puerarin 40%
37    Chlorogenic acid            25-98%
38    Centella Asiatica extract       Asiaticoside 10-90%
39    Wolfberry extract            Polysaccharides20-50%
40    Astragalus extract             Astragalosides0.3-20%,Polysaccharides 20-50%
41    Siberian Ginseng extract      Eleutheroside B+E 0.8%
42    Shiitake Mushroom extract    Polysaccharides10-30%
43    Hawthorn extract             Flavnones 10-30%
44    Ellagic acids                  40-95%
45    American Ginseng Extract    Ginsenosides 5-80%
46    Herba Andrographis Extract   Andrographolide 5-98%
47    Cordyceps extract            Polysaccharides10-40%
48    Red Yeast Rice extract        Lovastatin 0.4-3%
49    Agaricus blazei Murrill extract       Polysaccharides 30%
50    Bitter Melon extract               Charantin 10%
51    Valerian Root extract              Valerianic acid 0.4%,0.8%
52    Passion flower extract           Flavnones 4%
53    Ursolic acid                    98%
54    Gynostemma extract              Gypenosides 20-98%
55  Acetyl-resveratrol             98%